Research Activities:

LASER OPTIMAL is a human-oriented project, whose goal is the development of a novel strategy for safe tumor removal with laser therapy.


The new frontiers of laser therapy focus on the optimization of several technical aspects, such as measurement systems to monitor in real-time the thermal effect, to control the tissue damage; approaches for enhancing the selective absorption of the laser light by the target tissue; simulation-based tools, useful for the prediction of treatment outcome.


The rationale of LASER OPTIMAL is the control of the energy delivery in tumors, aiming to minimize the unwanted heat dispersion into the surrounding healthy tissue. The multidisciplinary team is working on the design of a patient-specific platform, useful to plan the treatment and to monitor the thermal outcome in real-time, in conjunction with the injection of nanoparticles for enhancing the selectivity of the treatment.


LASER OPTIMAL is a 5-year project funded by the ERC Starting Grant (Gant Agreement n. 759159) directed by Paola Saccomandi.


The Host Institution is the Politecnico di Milano, Partner Institutions are the Institute of Image-Guided Surgery (IHU) of Strasbourg, and the Beckman Research Institute of the City of Hope in California. The research team is based at the Department of Mechanical Engineering, in Milan.


Press the button “Research Activities” below for more information:


Scientific Publications:

🔗 Google Scholar (PI – Paola Saccomandi)
🔗 Scopus (PI – Paola Saccomandi) 
Paola Saccomandi. “I fondi messi a disposizione da Bruxelles: che cosa è stato fatto e che cos’hanno portato all’Italia. Uno sguardo anche sul green e occhi aperti sulla nostra bacheca con l’offerta dei posti di lavoro.”, Studio Aperto
Leonardo Bianchi. “LASER OPTIMAL project” Istituto Farmacologico Mario Negri, Milan, 08/11/2021 
Paola Saccomandi. “Generazione di talenti. In dialogo con le ricercatrici vincitrici di ERC Grant”, Stati Generali della Ricerca e dell’Innovazione, Villa Reale di Monza, 10/09/2021 
Paola Saccomandi. “Gender equality in research and innovation in the LASER OPTIMAL project”. GENEVA 2021 – 5th Annual Meeting IEEE Italy Section Women in Engineering Affinity Group Virtual event, 07/09/2021 
Martina De Landro. “Innovative measurement approaches for a specific real-time intraoperative control”, Workshop “Technological innovation for the precision medicine of tomorrow”, Politecnico di Milano, 10/06/2021 
Team. MeetMeTonigh. 28/11/2020.
Paola Saccomandi. “Gender equality in research and innovation in the LASER OPTIMAL project”. GENEVA 2021 – 4th Annual Meeting IEEE Italy Section Women in Engineering Affinity Group, Virtual event, 20/11/2020 
Paola Saccomandi. “Laser su misura” per il trattamento dei tumori. Milan, Italy, 27/03/2019.
Paola Saccomandi. Story of success: the passion for science from the high school to the academia. Nereto, Italy, 21/12/2019
Paola Saccomandi. Thermal techniques for cancer removal: a journey through state-of-the-art, research and clinical application. Haifa, Israel, 03/02/2020
Paola Saccomandi. Donne in Stem, Progetto Laser Optimal. Catania, Italy, 21/11/2019
Team. MeetMeTonigh. LASER OPTIMAL – EU corner. Milan, Italy, 27/09/2019
Paola Saccomandi. Radio Interview – Open day – LASER OPTIMAL project. Italy, 12/09/2018
Paola Saccomandi. LASER OPTIMAL website. 01/10/2018